Fibroblast growth factor 23 (FGF23) is a hormone primarily produced by bone cells that plays a crucial role in phosphate and vitamin D metabolism.
It is known to regulate phosphate levels by decreasing phosphate reabsorption in the kidneys and reducing vitamin D activation in the kidneys, leading to lower phosphate absorption in the intestines.
High levels of FGF23 are associated with conditions such as chronic kidney disease and certain bone diseases, while low levels can lead to phosphate retention and vitamin D excess, resulting in conditions like hyperphosphatemia and hypercalcemia.
FGF23 is essential for maintaining mineral homeostasis in the body, particularly in bone health, and any dysregulation in its levels can have significant implications for overall health.
A Fibroblast growth factor 23 test is performed to assess FGF23 levels in the blood, helping to diagnose and monitor conditions related to bone metabolism, kidney function, and mineral imbalances.
This test is particularly useful in evaluating patients with chronic kidney disease, as FGF23 levels can be elevated in these individuals, contributing to complications such as bone disorders and cardiovascular risks.
Monitoring FGF23 levels can also aid in the early detection of conditions like osteoporosis, where elevated FGF23 levels may indicate increased bone turnover and decreased bone mineral density.
The cost of a Fibroblast growth factor 23 test in India can vary depending on the laboratory, location, and the type of test being conducted. On average, the cost ranges from INR 1500 to INR 3000.
Factors influencing the cost of the test include the technology used for analysis, the reputation of the laboratory, and any additional tests that may be included in the panel along with FGF23 testing.
It is advisable to compare prices across different laboratories and consider any insurance coverage that may offset the cost of the test.
The normal range for Fibroblast growth factor 23 levels in the blood is typically between 17 and 54 pg/mL. Values outside this range may indicate underlying health conditions that need further evaluation.
Below is a table showing the interpretation of FGF23 levels:
High Fibroblast growth factor 23 levels in the blood can indicate conditions such as chronic kidney disease, genetic disorders affecting phosphate metabolism, and certain bone diseases like osteomalacia.
Elevated FGF23 levels are also linked to an increased risk of cardiovascular diseases, as they can lead to vascular calcification and arterial stiffness, contributing to heart complications.
Patients with high FGF23 levels may require further evaluation and management to prevent complications related to bone health, kidney function, and cardiovascular risks.
Low Fibroblast growth factor 23 levels in the blood may indicate conditions like hyperphosphatemia and vitamin D excess, which can lead to mineral imbalances and bone disorders.
In some cases, low FGF23 levels may be associated with conditions like hypophosphatemia and hypoparathyroidism, where phosphate and calcium metabolism are disrupted, affecting bone health and overall mineral homeostasis.
Patients with low FGF23 levels may require further testing and treatment to address underlying mineral imbalances and prevent complications related to bone metabolism and mineral homeostasis.
Fibroblast growth factor 23 testing plays a vital role in assessing bone health, kidney function, and mineral metabolism.
By understanding the implications of high and low FGF23 levels, healthcare providers can diagnose and manage conditions related to bone diseases, chronic kidney disease, and mineral imbalances effectively.
If you have concerns about your bone health or kidney function, consult with your healthcare provider to determine if a Fibroblast growth factor 23 test is appropriate for you.
Fibroblast growth factor 23 (FGF23) is a hormone that helps regulate phosphate and vitamin D levels in the body. It plays a crucial role in maintaining healthy bones by preventing excess buildup of phosphate, which can weaken bones.
FGF23 regulates phosphate levels in the body by promoting phosphate excretion through the kidneys and suppressing phosphate absorption in the gut.
Elevated FGF23 levels can indicate bone-related diseases like osteoporosis or chronic kidney disease, as FGF23 regulates phosphate metabolism and bone mineralization.
FGF23 levels can be tested with a blood test. High levels of FGF23 can help diagnose conditions like chronic kidney disease, hypophosphatemia, and certain genetic disorders affecting phosphate regulation in the body.
In chronic kidney disease, FGF23 levels can become elevated. This can lead to mineral and bone disorders in the body.
FGF23 decreases the activation of vitamin D in the kidneys, leading to lower levels of active vitamin D in the body.
High levels of FGF23 can be associated with lower bone mineral density.
FGF23 is a hormone that helps regulate phosphate and vitamin D levels in the body. It inhibits the production of active vitamin D and decreases the absorption of phosphate in the gut, leading to decreased bone turnover.
FGF23 levels are measured in the blood to evaluate the risk of fractures in patients with kidney disease. High levels of FGF23 are associated with an increased risk of fractures in these patients.
Manipulating FGF23 levels can help improve bone health in diseases like osteoporosis by regulating phosphate and vitamin D levels, which are important for bone strength.